We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, likely secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the proper coronary artery. Physicians and sufferers ought to be aware of the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity.

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However, testosterone in physiologic doses could even be helpful in sufferers with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in males with established coronary artery disease . Therefore, an interplay of endogenous elements of the patient’s threat profile as properly as the testosterone dosing may be problems with whether or not antagonistic events happen. Erythrocytosis has been reported as a potential impact of testosterone, which may be helpful in patients with anemia. The greatest risk of erythrocytosis happens with injectable types of testosterone compared with transdermal preparations, particularly in supraphysiologic doses. An enhance of as much as 44% of the baseline hematocrit has been reported .

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Unfortunately, the information on the usage of high dose anabolic steroids in people are primarily provided as case stories or small studies that lack sufficient control groups. In addition, the data available within the literature does not account for the steroid type or dose, as neither may be identified. Patients also may be taking concomitant stimulants, such as ephedra, which can confound information and the potential for adverse occasions. It is most likely going that the frequency of cardiac events is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 pure and synthetic derivatives of testosterone, may cause a large spectrum of scientific sequalae.

Case Report

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Moreover, testosterone has been used within the treatment of reduced muscle mass and bone density in addition to anemia. The role testosterone might play within the development of heart problems has more and more turn out to be the topic of current curiosity . Anabolic androgenic steroid use has elevated over the previous decade, regardless of its potential for adverse results. They continue to be used by Olympic level athletes, and have even spread to highschool degree athletes, noncompetitive bodybuilders and leisure athletes (Sullivan et al 1998; Dhar et al 2007).

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